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Role of endogenous gaseous transmitters and regulatory peptides in the pathogenesis of idiopathic pulmonary fibrosis

FANG Liping1,TANG Chaoshu2,LIU Xinmin1 (1.Department of Geriatrics;2.Institute of Cardiovascular Disease,Peking University First Hospital,Beijing 100034,China)  
Idiopathic pulmonary fibrosis(IPF) is a chronic,progressive lung disease with unknown etiology and uncertain pathogenesis,characterized by fibroproliferation,destruction of the lung parenchyma and deposition of extracellular matrix.Recently,it was reported that endogenous gaseous transmitters(nitric oxide,carbon monoxide and hydrogen sulfide) and regulatory peptides(angiotensin II,relaxin and urotensin II et al) play a key role in regulating pulmonary fibrosis and may be critical to the pathogenesis and development of IPF.
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