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Advances of signal transduction of macrophage migration inhibitory factor

ZHANG Shaohui1,GAO Dongsheng2 (1.Tianjin Medical University,Tianjin 300070;2.Department of Cardiology,Affiliated Hospital of Jining Medical College,Jining Shandong 272029,China)  
Macrophage migration inhibitory factor is a multipotent cytokine and be widely distributed in the body,it may be involved in a variety of physiological and pathological responses,its signal transduction mechanism is complex and extensive,such as extracelluclar-signal regulated kinase 1/2(ERK1/2) signal transduction pathway,NF-κB and Jab 1 signal transduction pathway.It is closely related to many complex autoimmune diseases,but the MIF signal transduction mechanisms were still not completely clarified.
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