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Current concept review:mimecan gene

NIAN Di1,WANG Ping2 (1.Department of Pathology,Bengbu Medical College,Bengbu Anhui 233030;2.Anhui Key Laboratory of Infection and Immunity,Bengbu Anhui 233000,China)  
Mimecan belongs to a family of small leucine-rich proteoglycans(SLRPs) including 3 isoforms(osteoglycin,keratan sulfate glycoprotein,and mimecan),which is expressed in a variety of human tissues and has an important function of physiology and pathology.Mimecan plays an important role in the process of collagen fibrillogenesis,cellular growth,differentiation,and migration.Also is closely related to the diseases of fibrosis and bone.Moreover,the expression of mimecan in colorectal tumors,pituitary tumor and liver cancer is different from the corresponding normal tissue,suggesting that it may be correlated with the occurrence of these tumors.
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