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Effects of poly(ADP-ribose)polymerase during shock and ischemia-reperfusion injury

ZHOU Xuewu,LIU Liangming (State Key Laboratory of Trauma,Burns and Combined Injury,Second Department,Research Institute of Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,China)  
Poly(ADP-ribose)polymerase is activated during hemorrhagic shock,endotoxic shock and septic shock,as well as ischemia-reperfusion injury in the main organ of the body.Moreover,poly(ADP-ribose)polymerase is involved in the pathogenesis of shock and ischemia-reperfusion injury.Inhibition of poly(ADP-ribose)polymerase has preventive and therapeutic effects on the treatment of shock and ischemia-reperfusion injury.
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