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Relation between FcγR and autoimmune diseases and targeted therapy by FcγR

XUE Yuan,XU Huaxi (Department of Immunology,Institute of Clinical Laboratory Medicine,Jiangsu University,Zhenjiang Jiangsu 212013,China )  
IgG Fc receptor(FcγR),expressed on the surface of most leukocytes,is an important immunoregulatory molecule.FcγR plays an important role both in cell immunity and humoral immunity.On certain circumstances,FcγR may cause immune damage to the body.Recently,plenty of researches have shown that FcγR genetic polymorphism is related to the pathogenesis of autoimmune diseases.In this review,we summarized the role of FcγR and its targeting intervene in immune diseases.
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