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Advances of spontaneous lupus-prone mouse model

YU Likai1,HUANG Anbin1,HOU Xiaohua2 (1.Department of Rheumatology;2.Department of Gastroenterology,Union Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)  
Research on spontaneous lupus-prone mouse model is important for the exploration of the causes,pathogenesis and treatment of systemic lupus erythematosus in human being.There have been more studies mainly on spontaneous mouse model BXSB / MpJ,NZB/W.F1 and MRL / lpr three strains in recent years.The source and genetics,clinical and organizational characteristics,autoantibodies,abnormal immune cells and experimental treatment of three strains have respective characteristics.
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