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《International Journal of Pathology and Clinical Medicine》 2009-04
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Expresssion of E-cadherin in colorectal carcinoma and the invasion and metastasis

XU Shengmei,MA Hongmei,GUO Dong(Department of Pathology,Affiliated Futian Hospital of Guangdong Medical College,Shenzhen 518033,China)  
Objective To investigate the relation between the invasion and metastasis of colorectal carcinoma and the expression of E-cadherin.Methods The immunohistochemistry method and the in situ hybridization method were used to detect the expression of E-cadherin in normal colorectal mucosa,colorectal adenomas,and colorectal carcinomas tissues.Results The positive rate of mRNA and protein of E-cadherin in colorectal carcinoma were lower than that of normal colorectal mucosa and adenomas tissues (P0.01);the positive rate of E-cadherin were decreased concomitantly with decrease in differentiation of CRC and the increase in Dukes stages;the positive rate of E-cadherin in colorectal carcinoma of the metastasis of lymph node and distant organ was lower than that of the negative ones(P0.01,P0.05).Conclusion The decrease and absence of E-cadherin play an important role in the invasion and metastasis of colorectal carcinoma.
【CateGory Index】: R735.3
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