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《International Journal of Pathology and Clinical Medicine》 2009-04
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Clinical value of liver biopsy for infantile hepatitis syndrome

LIU Yuling1,MI Xianjun2,ZHOU Tao1,FU Simao1(1.Department of Pediatrics;2.Department of Pathology,Boai Hospital of Zhongshan City,Southern Medical University,Zhongshan Guangdong 528403,China)  
Objective To investigate the clinical value of liver biopsy in patients with infantile hepatitis syndrome (IHS).Methods A total of 20 patients with HIS were undergone percutaneous liver biopsy.All liver biopsy specimens received routine pathological examination,and were divided into 4 grades according to the extent of hepatocyte degeneration,necrosis,and cholestasis.All the patients were divided into 2 groups according the pathological results.Grade Ⅰand Grade Ⅱ were included in Group 1,Grade Ⅲ and Grade Ⅳ were included in Group 2.Clinical manifestation,liver function test,antibody for cytomegalovirus,gallbladder development by echo and prognosis were compared between the 2 groups.Results There were 12 patients in Group 1,which included 4 in Grade Ⅰ and 8 in Grade Ⅱ.Ten patients fully recovered in Group 1.There were 8 patients in Group 2,which included 5 in GradeⅢ and 3 in Grade Ⅳ.Two patients fully recovered,whereas 6 were not fully recovered in Group 2.There were 2 atresia of extrahepatic bile duct (confirmed by surgery).Conclusion The prognosis of Group 1 is better than that of Group 2;liver biopsy has prognostic value in patients with IHS.
【CateGory Index】: R725.7
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