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Estrogen receptor α coactivator and breast cancer

ZHONG Yaqin1,2,ZHONG Jing1,2,WEN Gebo1,2 (1.Clinical Research Institute;2.Department of Endocrinology,First Hospital Affiliated to Nanhua University,Hengyang Hunan 421001,China)  
During the development of breast cancer,the activity of estrogen receptor α(ERα) signaling pathway can be enhanced.One of the important reason is the change of ERα coregulors.The coregulators can be divided into coactivators and corepressors.The present review focuses on the ERα coactivator in combining with ERα,with a specific emphasis on the ERα activator activities in breast cancer.
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