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《International Journal of Pathology and Clinical Medicine》 2009-04
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Extracellular calcium sensing receptor and it's role in cardiovascular system

WANG Zhenhuan,HE Fang (Department of Pathophysiology,Medical College of Shihezi University;Ministry of Education Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi Xinjiang 832002,China)  
Calcium receptor cells(CaR),also known as calcium sensing receptor (CaSR),plays a key role in regulating the balance of the extracellular calcium in the body.CaR does not only distribute in the organs (such as parathyroid,bone,kidneys,and intestines) which are related to calcium transfer and homeostasis,but also widely distribute in the tissues which has nothing to do with the stability of calcium.In addition to maintaining calcium homeostasis by PLC,PIK,MAPK,and other signaling pathways,CaR also has other functions such as the protection of cells against apoptosis and cell proliferation.In the cardiovascular system,CaR plays important physiological and pathological roles.This review summarized the progress of CaR on the structure,function,and signal transduction.Its role in the cardiovascular system was highlighted.
【Fund】: 国家自然科学基金(30860099)~~
【CateGory Index】: R54
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