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《International Journal of Pathology and Clinical Medicine》 2009-04
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Biomedical application of nuclear localization signal peptides

CHEN Benke1,2,WANG Xiaowen1,TANG Jintian1 (1.Department of Engineering Physics,Tsinghua University,Key Laboratory of Particle & Radiation Imaging,Ministry of Education of the People's Republic of China,Beijing 100084;2.Department of Biopharmaceuticals,Beijing University of Chinese Medicine,Beijing 100102,China)  
A nuclear localization signal (NLS) is an amino acid sequence which consists of one or more short sequences of positively charged lysines or arginines.It is a necessary signal sequence that mediates the proteins entering the cell nucleus through the nuclear pore complex.Eukaryotic nuclear proteins and viral proteins contain NLS,and the protamine is widely used as a natural NLS peptide.As the NLS can mediate many substances,such as DNA,protein,and nanoparticles,entering the cell nucleus,biomedical applications of NLS peptide have been widely studied.
【Fund】: 北京市科委项目(Z07000200540704);; 清华大学裕元医学基金~~
【CateGory Index】: R318
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