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《International Journal of Pathology and Clinical Medicine》 2009-04
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Regulation of the phagocyte NADPH oxidase activation

WANG Wei,TANG Shengsong (Institude of Phamacy and Phamacology,Nanhua University,Hengyang Hunan 421001,China)  
The phagocyte NADPH oxidase is a multicomponent activatable enzyme comprising the major phagocyte antimicrobial systems.The oxidase system includes both membrane-bound and soluble cytosolic proteins.The primary feature of this enzyme is stimulus-dependent activation and which mechanism is the phosphorylation and translocation of a complex of cytosolic factors to the membrane,where they associate with a flavocytochrome enzyme.The fully assembled complex functions as an electron transport system,moving electrons from cytosolic NADPH to molecular oxygen to form superoxide anion(O2-),which,along with subsequent reactive products called respiratory burst,exerts microbicidal and cytotoxic activities.This activated process of NADPH oxidase is regulated by regulatory subunits,upstream mediators,and the other factors.
【Fund】: 湖南省自然科学基金(08JJ5004 09JJ3060);; 湖南省教育厅科技计划重点项目(07A059)~~
【CateGory Index】: R392.1
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