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《International Journal of Pathology and Clinical Medicine》 2009-04
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Cardioprotection role of hypoxia-inducible factor-1

WANG Han,XU Minguang (Department of Physiology,Hainan Medical College,Haikou 571101,China)  
Hypoxia-inducible factor-1(HIF-1) is an oxygen-dependent transcriptional factor,which plays a key role in oxygen homeostasis.Under hypoxia conditions,HIF-1 is expressed in the cell steadily.HIF-1 controls the expression of a variety of genes,and its protein products play crucial roles in energy metabolism,cell survival and proliferation,angiogenesis,erythropoiesis,tumor growth,and cancer multiple drug resistance.The various degree of hypoxia exists in many cardiac diseases.The body can show compensation response to hypoxia.The activation of HIF-1 is of very importance to the compensation of the myocardium under hypoxia conditions.HIF-1 can regulate many gene expression under hypoxia conditions such as vascular endothelium growth factor,inducible nitric oxide synthase,heme oxygenase-1,endothelin-1,and atrial natriuretic peptide,which may be involved in the compensation mechanism and therefore lead to the cardioprotection.
【Fund】: 海南省自然科学基金(309035);; 海南省教育厅高校科研基金(Hjkj2009-55)~~
【CateGory Index】: R541
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