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《International Journal of Pathology and Clinical Medicine》 2009-04
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Role of cortistatin in the immune system

LIU Lin1,DING Wenhui1,TANG Chaoshu2 (1.Department of Cardiology,First Hospital;2.Institute of Cardiovascular Research,Peking University,Beijing 100034,China)  
Cortistatin(CST) is a new member of somatostatin neuropeptide family,widely distributed in central nervous system,peripheral endocrine organs and immune organs.It's able to bind to somatostatin receptors,ghrelin receptors and MrgX2 receptors.CST has been shown to regulate the neuroendocrine functions,to induce immune tolerance as well as to inhibit inflammatory reactions.CST can function as an anti-inflammatory factor with therapeutic potential in sepsis,Crohn's disease and rheumatoid arthritis.Since it can inhibit the proliferation and migration of vascular endothelial cells,CST might also have clinical significances in the development and therapy of cardiovascular diseases
【CateGory Index】: R392
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