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Molecular characteristics of Daxx and stress

XU Guina,LIAO Duanfang,TUO Qinhui(Institute of Pharmacy and Pharmacology,University of South China,Hengyang Hunan 421001,China)  
As a highly conserved nuclear protein containing 4 different structural domains,Daxx plays a significant role in apoptosis and regulation of transcription.Two putative nuclear localization signals are associated with the diverse biological functions of Daxx and are essential for the interactions among multiple proteins.Daxx is closely related to many pathophysiological processes such as oxidative stress,myocardial ischemia insult and so on,supporting that Daxx is critical for cardiovascular system.
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