Angiogenesis and the regulation mechanism in glioma
HUANG Chunhai1,2,LI Xuejun2,YAUN Xianrui2 (1.Department of Neurosurgery,First Affiliated Hospital,Jishou University,Jishou Hunan 416000;2.Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha 410008,China)
Studies in vitro show that the growth of solid tumor is vessel dependent.Solid tumor usually stops growing when its diameter is over 2 mm due to lack of new vessel to supply blood.Glioma is one of the most malignant tumor in vascularization.As a solid tumor,the vascularization in glioma also includes vasculogenesis and angiogenesis.Vasculogenesis is defined as the differentiation of precursor cells(angioblasts) into endothelial cells and the de novo formation of a primitive vascular network,whereas angiogenesis is defined as the growth of new capillaries from pre-existing blood vessels.Angiogenesis,which plays a significant role in the development of tumor,has become a new target for the prognostic evaluation and therapy of glioma.Recently,the research in exploring the mechanism of angiogenesis has attracted great attention.
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