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RASSF1A and its role in tumorigenesis

XIAO Weisheng,LIAO Aijun(Department of Gastroenterology,First Affliated Hospital,Nanhua University,Hengyang Hunan 421001,China)  
RASSF1A(Ras-assotiation domain family 1 A) is a recently discovered new tumor suppressor.Recently,it has been shown that silencing of RASSF1A was found in many tumors.Although it can be inactivated by gene deletion or mutations,the most common reason for RASSF1A dyfunction is due to the silence of the gene by inappropriate methylation in promoter region.This epigenetic mechanism is thought as an early incidence and plays a major role in the development of cancer.RASSF1A contains several structural domains and is an potential effector of the Ras oncoprotein.It is able to bind to the activated Ras and participates in regulating the signal pathway of apoptosis and cell cycle.It is closely associated with the development of tumor and exerts multiple functions in cellular apoptosis,cycle,proliferation,differentiation and stability.
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