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Progress in the study on EPO/EPOR and its signal transduction

GE Quanxing1,CHEN Ken1,LONG Youming1,WANG Hui2(1.Department of Internal Medicine,Clinic College of Medicine,Guangdong Pharmaceutical University,Guangzhou 510800; 2.Department of Pharmacology,College of Chinese Materia Medica,Guangdong Pharmaceutical University,Guangzhou 510006,China)  
Erythropoietin(EPO) and erythropoietin receptor(EPOR) are the essential key cytokines in regulating the proliferation,differentiation and survival of erythroid progenitors.Recently,more and more studies have demonstrated that EPOR also exists in other type of cells in addition to normoblasts,suggesting that EPO and EPOR may have much more extensive biological functions.Here,we reviewed the intracellular signal transduction pathways activated by the EPO and the underlying mechanisms.
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