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Role of microRNAs in cardiovascular disease

XU Jingou,OU Hesheng(Institute of Pharmacy and Pharmacology,Nanhua University,Hengyang Hunan 421001,China)  
MicroRNAs(miRNAs) is a kind of 21~28 nt single-stranded,non-coding small molecular RNA,which can regulate thousands of genes through binding to 3′-UTR of target genes in a pattern of full or partial complementary pairing,and results in degradation or translation inhibition of target genes.Recently,it has been shown that miRNAs has become a key regulator of many bioprocess including growth and development,cell proliferation,differentiation and apoptosis.To elucidate the role of microRNAs in diseases may provide a novel strategy for the therapy of many diseases.This review summarized the progress in the study on role of miRNAs in cardiovascular diseases.
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