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RAGE mediates the extracellular effects of S100 protein

YANG Jingjin,CAO Renxian,WEN Fang(Department of Endocrinology,First Affiliated Hospital,Nanhua University,Hengyang Hunan 421001,China)  
The S100 protein family comprises at least 25 members and participates in regulating a large variety of intracellular activities.Recently,it has been shown that some S100 proteins are released by a non-classical pathway and exert regulatory role by interacting with RAGE.The interactions between S100 and RAGE might play an important role in the development of inflammatory and tumor processes.
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