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《Journal of Clinical and Pathological Research》 2014-01
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Acute cerebral infarction risk factors and the level of serum uric acid

LIU Qing;LI Yongguang;Department of Neurology, Union Hospital of Tangshan;  
Objective: To investigate the correlation between risk factors of acute cerebral infarction(ACI) and the level of serum uric acid(SUA) and the clinical signii cance. Methods: A total of 50 patients with ACI were enrolled to measure the levels of SUA, total cholesterol(TG), triglycerides(TC), low density lipoprotein cholesterol(LDL C),high density lipoprotein cholesterol(HDL C), high sensitivity C reactive protein(HSC), and i brinogen(FIB). Results: h e average SUA level of all patients at er ACI was(310.18±100.56)μmol/L, in which 10 patients were hyperuricemia. h e HSC level was elevated when SUA≥360 μmol/L. There was a significant difference in the level of HSC between the ACI patients with and without hyperuricemia(P=0.002), while there were no significant difference in the levels of TG(P=0.907), TC(P=0.194), HDL C(P=0.411), LDL C(P=0.396), FIB(P=0.159) between the 2 groups. SUA level in men [(348.41±98.78) μmol/L] was higher than that in women[(280.14±92.93)μmol/L; P=0.016]. Among the 50 ACI patients, 47 complicated with hypertension, 19 with diabetes, and 36 with coronary heart disease. There was no significant difference in SUA levels between ACI patients with and without above mentioned complications(all P0.05). Conclusion: Hyperuricemia in patients with ACI displays the similar incidence to general population while the risk in hyperuricemia in men is higher than that in women. Risk factors(such as hypertension, diabetes and coronary heart disease) for ACI show lit le inl uence on SUA while SUA might inl uence ACI through several pathways.
【CateGory Index】: R743.33
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