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《Journal of Clinical and Pathological Research》 2014-01
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Progress in study on the regulation of cholesterol metabolism

LI Tianping;XUAN Guiping;TUO Qinhui;Institute of Pharmacy and Pharmacology, University of South China;Department of Pharmacology, College of Pharmacy, Hunan University of Chinese Medicine;  
The metabolism of cholesterol, including biosynthesis, catabolism and reverse cholesterol transport, is closely related to a large number of diseases especially atherosclerosis. As a nuclear transcription factor, sterol regulatory element binding proteins can accelerate the expression and activity of the key rate limiting enzymes(such as 3 hydroxy 3 methylglutaryl coenzyme A reductase),which is modulated by FoxO3 / Sirt6 complex,3β hydroxysterol ?(24) reductase and death domain associated protein(Daxx). The excessive cholesterol, antiported from peripheral tissue, was catabolized to bile acids and steroid hormones in liver, which is regulated by spermidine/spermine N1 acetyltransferase, Prospero related homeodomain protein 1 and Daxx. Reverse cholesterol transport(RCT) plays a key role in the form of atherosclerotic plaque and necrotic core. It is likely that TNFα and red blood cells are involved in the RCT mediated by macrophages.
【Fund】: 国家自然科学基金(30971267 31371161 81173047);; 湖南省高校创新平台开放基金项目(12K096);; 湖南省自然科学基金(14JJ1024)~~
【CateGory Index】: R543.5
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