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《Journal of Clinical and Pathological Research》 2014-01
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Role of CXCR4 in the occurrence and development of tumors

WANG Feng;ZHANG Sheng;Department of Pathology, First Ai liated Hospital, Fujian Medical University;  
The chemokine receptor 4(CXCR4) belongs to the large super family of G protein coupled seven span transmembrane receptors and stromal derived factor 12 is the only known ligand for CXCR4. It has been shown that CXCR4 expresses in malignant cells from 23 different types of cancer and plays an important role in tumor proliferation, invasion, metastasis and prognosis. Targeted therapeutic approaches against CXCR4 might attract great attention in gene therapy for cancers.
【Fund】: 福建医科大学第一临床学院学科带头人培养对象专项基金(JXK200724)~~
【CateGory Index】: R730.2
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