Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Clinical and Pathological Research》 2014-01
Add to Favorite Get Latest Update

Structure and function of i lamin A

WANG Jie;ZHU Tienian;Department of Oncology, Bethune International Peace Hospital;  
Filamin a(FLNa) is the first non muscle actin filament cross linking protein. It has over 90 binding partners including channels, receptors, intracellular signaling molecules and even transcription factors, which play a role in conformity cell mechanics and signal transduction. Due to this diversity, mutations in human FLNa genes can result in a wide range of anomalies with moderate to lethal consequences including malignant tumor. h is review focuses on the research progress of molecule structure and functions of FLNa in diseases development.
【Fund】: 国家自然科学基金(81071846);; 河北省自然科学基金(H2013505059);; 河北省科技厅国际合作项目(12396107D);; 吴阶平医学基金(320.6750.12604)~~
【CateGory Index】: R541
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved