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《Journal of Clinical and Pathological Research》 2014-01
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Research progress in neuroprotection of curcumin on Alzheimer's disease

XU Ke;LI Yu;First Clinical College, Chongqing Medical University;Neuroscience Research Center, Chongqing Medical University;  
Alzheimer's disease(AD), a neurodegenerative disease, is one of the main reasons leading to dementia. Curcumin, a polyphone compound, is an active yellow polyphenol pigment of turmeric. Curcumin has been attracted highly attention due to its outstanding safety proi le and a number of pleiotropic actions with potential for neuroprotective effects. In recent years, it has been suggested that curcumin displays protective effect against the development of AD in vivo as well as in vitro. As an antioxidative agent, curcumin exerts the neuroprotective effect on AD through decrease in formation of reactive oxidative species and maintaining the balance of redox. In addition, it also exerts regulatory effects on signal molecules, such as NF κB, β amyloid precursor protein, β site APP cleavage enzyme 1, and nuclear factor erythroid 2 related factor 2.
【Fund】: 国家自然科学基金(81271426);; 重庆医科大学大学生科学研究与创新实验基金(201330)~~
【CateGory Index】: R749.16
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