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The clinical value of liquid based cytologic test in diagnosis of lung space occupying lesions

LIU Hanzhong;WANG Lan;HE Huihua;TU Zhen;XIAO Jing;XIAO Lan;LI Bei;DAI Yifei;Department of Pathology, Central Hospital of Xiaogan;  
Objective: To study the clinical value of the liquid-based cytology(the liquid based cytologic test, in LCT) production in CT-guided transthoracic intrapulmonary tumor needle suction cytology in order to improve the efficiency of the clinical and pathological diagnosis, improve lung tumor puncture needle aspiration cytology diagnostic accuracy, especially in line with the rate of positive rate of diagnosis of Lung Space Occupying Lesions. Methods: Collected guide transthoracic intrapulmonary tumor fine needle aspiration cytology(fine the needle aspiration cytology, FNA) with complete data cases of 831 cases of pulmonary tumor patients with CT and 295 cases(35.50%) in conventional smear diagnosis, the diagnosis of 536 cases(64.50%) in LCT system. Compare of LCT producer method with the traditional paper method in collecting diagnostic cell preservation and producer effect, cytological characteristics, the ratio of the mass organizations, the sensitivity and specificity of cytologic diagnosis. Results: About 71.12% of the final diagnosis of 831 cases was obtained by surgical resection or followup results. While LCT mass organizations, the probability was 64.50%(346/536) and mass organizations agreed the chance of histopathologic diagnosis was 45.20%(242/536) were significantly higher than the traditional method of 25.08%(74/295) and 7.46%(22/295), both have statistically significant difference(P0.01). LCT method detection sensitivity of lung cancer was 87.64%, the sensitivity of traditional method was 38.78%, both have statistically significant difference(P0.01), have the actual clinical significance. Conclusion: CT guided through the chest wall, lungs tumor puncture liquid-based cytology diagnosis to ensure that clinical take samples to get adequate and timely fixed, remove the interference of blood mucus and other smears, the cell distribution is more uniform, more focused diagnostic cells. cell morphology more clearly, and help get the bar of mass organizations to paraffin sections of pathological diagnosis and histological diagnosis, the lungs of tumor invasive diagnostic rate, especially to raise the positive rate of diagnosis of lung cancer and lung cancer histological type the compliance rate, and simple, repetitive, and improve the efficiency of the pathologist's diagnosis.
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