Loss of expression of tumor suppressor gene SCARA5 in human breast cancer
CHEN Lili;FU Fangmeng;WANG Chuan;Department of Breast Surgery, Fujian Medical University Union Hospital;
Objective: To investigate the expression of SCARA5 m RNA in human breast cancer; and explore its clinical significance. Methods: Fifty five pair samples of breast cancer and adjacent normal tissue were obtained. Total RNA was extracted and m RNA expression of SCARA5 was proceeded by real-time fluorescence quantitative RTPCR. Results: Of the total 55 pairs of sample, 45 pairs of the SCARA5 expression were down-regulated(81.82%), 10 pairs was up-regulated, statistically significant difference in the expression(P0.05), but SCARA5 m RNA level was not associated with clinicopathological factors. Conclusion: SCARA5 gene expression in most breast cancer was reduced. Abnormally expression of SCARA5 contributes to genesis of breast cancer.