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A systematic analysis between NQO1 gene polymorphism and susceptibility of lung cancer

ZHANG Ling;YAN Han;WANG Siyu;HONG Jianmao;WANG Xudong;LIU Sicheng;LI Zhongen;ZHANG Yu;CAO Bangwei;Department of Oncology, Beijing Friendship Hospital, Capital Medical University;  
Objective: To explore the relationship between NAD(P)H:quinine oxidoreductase 1(NQO1) gene polymorphism and susceptibility of lung cancer. Methods: CNKI, Chongqing VIP database, Wanfang database, Medline, Pub Med, Embase, Science Online and other databases were used to search a large number of case control studies associated with NQO1 gene c DNA609 polymorphism and susceptibility of lung cancer. Quality assessments were done for every included research study. The systematic analysis was conducted by meta-analysis software Review Manager 5.0. Results: The meta-analysis included 26 research studies finally. In both the TT and CT+TT genotype frequencies of NQO1 gene c DNA609, there were no statistical significances between cases and controls in overall(OR=1.02, 95% CI: 0.91~1.15, P=0.68; OR=0.98, 95% CI: 0.89~1.08; P=0.65). Subgroup analyses on different races and different pathological types show no statistical significance between cases and controls either(P≥0.05). Conclusion: The findings suggested that NQO1 gene c DNA609 might not contribute to the susceptibility of lung cancer.
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