The role of HIF-1 and CD24 in colorectal cancer
DING Xiujie;ZHANG Rui;Department of Nuclear Medicine, Liaoning Cancer Hospital & Institute;Department of Colorectal Surgery, Liaoning Cancer Hospital & Institute;
Objective: To determine the HIF-1 and CD24 expression in colorectal cancer and investigate the relationship between the expression of HIF-1 and CD24 and the prognosis of the patients with colorectal cancer. Methods: The tissues of cancer center and peritumoral of esophageal carcinoma were collected by surgery. The levels of HIF-1 and CD24 proteins were detected by using Western-blot. The correlation between CD24 protein and HIF-1 protein was evaluated by using Pearson correlation analysis. Kaplan-Meier survival curve analysis was used to analysis the relationship of CD24 and HIF-1 protein with the prognosis of patients with colon cancer. Results: The levels of HIF-1 and CD24 expression were higher in cancer tissues than that in normal tissues(P0.05). HIF-1 expression was not associated with sex, age, differentiation, lymphatic invasion, venous invasion, tumor size and p N category. CD24 expression was not associated with sex, lymphatic invasion, venous invasion, tumor size and p N category, but related with age of patient and tumor differentiation. The survival rate of the patients with both HIF-1 and CD24 expression was lower than the patients with HIF-1 or CD24 expression by using KaplanMeier survival curve analysis(P0.05). Conclusion: Abnormal high HIF-1 and CD24 expression was observed in colorectal cancer tissues, which suggest that there was association between HIF-1 or CD24 and the development of colorectal cancer.