Effects of endothelial-specific and endothelial-enriched miRNAs on vascular function
WU Yan;YANG Zhichun;PENG Jun;Department of Pharmacology, School of Pharmaceutical Science, Central South University;
mi RNAs, widely presenting in eukaryotes, are a group of non-coding small RNAs generated from hairpin mi RNA precursors(pre-mi RNAs) by Rnase-Dicer. It has been demonstrated that mi RNAs possess the characteristics of tissue specificity and sequential expression and only express in particular organs at stages of special developments. mi RNAs play an essential role in cell differentiation, proliferation and apoptosis. Numerous studies show that endothelial-specific and endothelial-enriched mi RNAs exert effects on vascular function. For example, endothelialspecific mi R-126 plays a vital role in inflammation, angiogenesis, as well as endothelial integrity, while endothelialenriched mi R-221/222 and mi R-21 participate in regulation of inflammation, angiogenesis, and endothelial senescence and so on.