Research advancement on BNIP3 in regulating tumor cell autophagy and death
LI Lijun;TANG Shengsong;Institute of Pharmacy and Pharmacology, University of South China;
BCL2 and adenovirus E1B19 k Da interacting protein 3(BNIP3) is protein with homologous to BCL2 in the BH3 domain, which are the atypical member of the BH3-only subfamily. When BNIP3 over-expressed, the vast majority of them are located in the mitochondrial outer membrane. Although many other proteins may induce cell mitophagy or apoptosis more efficiently than BNIP3, the ability of BNIP3 associating mitophagy with apoptosis and ultimately affecting the fates of cell makes it more significance than other single promote mitophagy or apoptosis protein. Here we review the role of BNIP3 in mitophagy and apoptosis of the tumor, and discuss potential mechanisms by which they may function.