The advanced research of FBXW7 in colorectal cancer
GONG Jian;HUO Jirong;Department of Gastroenterology, Second Xiangya Hospital of Central South University;
The ubiquitin proteasome system(UPS) is important in eukaryotic for protein degradation, whose dysregulation is associated with the occurrence and development as well as prognosis of tumors. F-box family proteins play a pivotal role in UPS. FBXW7 is one of the most characterized proteins in F-box family. According to the recent study, the abnormal expression of FBXW7 is closely related to malignant tumor. Colorectal cancer is the third most common malignant tumor in the world, and its incidence has a tendency to increase year by year. This article summarized the advanced research of FBXW7 in colorectal cancer.