Post-translational modification of DAXX
ZHANG Yan;LI Tianping;TUO Qinhui;Institute of Pharmacy and Pharmacology, University of South China;Hunan University of Chinese Medicine;
Fas death domain-associated protein DAXX, a highly conserved and multifunctional protein that is widely distributed in the nucleoplasm, nucleolus, cytoplasm, heterochromatin, promyelocytic leukemia nuclear bodies(PML-NBs) and other subcellular localization, plays an important role in the regulation of transcription and apoptosis. This regulation of DAXX involves a series of post-translational modifications, including ubiquitination, ubiquitin-like protein modification and phosphorylation, through modification, causing the translocation of DAXX among subcellular regions and the changes of physiological functions. This review will provide a summary for post-translational modifications of DAXX.