Research progression of the relationship between accumulation of ectopic lipid metabolites and insulin resistance
GONG A'juan;LI Sumei;Department of Endocrinology, Anhui Provincial Hospital, Anhui Medical University;
Insulin resistance is closely related with the pathogenesis for many of metabolic diseases, including type 2 diabetes(T2D), nonalcoholic fatty liver disease(NAFLD) and atherosclerotic heart disease. Mainly due to non-adipose tissue insulin resistance is the accumulation of ectopic lipid metabolites. The accumulation of ectopic lipid metabolites is closely linked to changes in fatty acid uptake, lipogenesis, and energy expenditure that converge to promote the accumulation of specific lipid metabolites(diacylglycerols and/or ceramides) in liver and skeletal muscle, leading to impaired insulin signaling and insulin resistance. The purpose of the article is to summarize the research in recent year about the mechanism of the accumulation of specific lipid metabolites(diacylglycerol, ceramide) results in insulin resistance.