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Research progress in ROS1 gene in non-small cell lung cancer

ZHENG Jiaoyun;LI Daiqiang;Department of Pathology, Second Xiangya Hospital, Central South University;  
Lung cancer is one of the most common malignant cancers. ROS1 is an oncogene which is newly found in non-small cell lung cancer(NSCLC). The protein encoded by ROS1 is a member of receptor tyrosine kinase superfamily, and it plays a vital role in cell growth and cell survival. More and more studies demonstrated that the alteration of ROS1 would be a new molecular target for individualized treatment of NSCLC. This review focus on the feature of ROS1 rearrangements in NSCLC, the detection methods of ROS1 rearrangement, and the research progress about taking ROS1 rearrangement as drug target in NSCLC
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