The regulation of Rho GTPases on glomerular podocytes' specific slit diaphragms cytoskeleton proteins
XIAO Chuan;LIU Xueguang;Department of Pathology, Basic Medical College, Fudan University;
Glomerular podocytes are highly differentiated cells with unique architecture and function, and constitute the outer layer of glomerular filtration membrane. Their unique morphologies mainly depending on the dynamic actin cytoskeleton network are crucial for their physiological functions. Rho GTPases are involved in a variety of cellular activities, and play a central role in cytoskeleton regulation. The regulation on podocyte cytoskeleton by Rho GTPases, especially the cytoskeleton proteins located on slit diaphragms, is reviewed.