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《Journal of Clinical and Pathological Research》 2015-01
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Influence of glycosylated hemoglobin on long-term prognosis of elderly patients with acute myocardial infarction treated with percutaneous coronary intervention

JIA Ning;FENG Yan;WANG Mingsheng;HONG Heng;TAN Liling;ZHAO Xia;Wang Lei;LI Mingchang;WANG He;XIAO Yi;Department of Cardiology, Beijing Shijingshan Hospital, Shijingshan Teaching Hospital of Capital Medical University;Troops 68036 PLA;  
Objective:To evaluate the influence of glycosylated hemoglobin(HbAlc) on long-term prognosis of elderly patients with acute myocardial infarction treated with primary percutaneous coronary intervention(PCI).Methods:A total of 233 acute myocardial infarction patients with age 60 years old who received primary PCI during June 2008 to December 2012 and followed up 1 year after charge were included in this study.Blood sample for HbAlc were obtained on the first 24 h after admission.Patients were classified into three groups:group Ⅰ(HbAlc5.6%;n=46);group Ⅱ(5.7% HbAlc 6A%;n=92);and group Ⅲ(HbAlc 6.5%;n=95).Results:The patients were followed up for a mean period of(977±438) days.Totally 12 patients(5.2%) died and MACE occurred in 18patients(7.7%).The patients were divided into diabetes group and diabetes-denied group.MACE and mortality in one year which were equal in diabetes-denied was higher in group Ⅲ(12.5%) compared with group Ⅱ(2.6%)and group Ⅰ(0%;P=0.026),but there were not different between group Ⅱ and group I.In diabetes group,group Ⅰand group II were merged to compare with group Ⅲ,the differences of MACE and mortality in one year were not found between them in the result.After multivariate analysis,HbAlc(hazard ratio,1.258;95%CI:1.114-1.421;P0.00l) was independently associated with long-term(more than 1 year) mortality.Conclusion:The HbAlc is an independent predictor of long-term outcomes in elderly patients with acute myocardial infarction treated with primary PCI.HbAlc 6.5 were associated with MACE and mortality in 1 year for the diabetes-denied patients.
【CateGory Index】: R542.22
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