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《Journal of Clinical and Pathological Research》 2015-01
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A preliminary study on the relationship between circulating tumor cells count and clinical features in patients with non-small cell lung cancer

WAN Jiawei;SHEN Hongyuan;HUANG Hongyu;HAN Zhijun;YAN Zihe;GAO Mingzhu;HUANG Xinxiang;School of Medical Science and Laboratory Medicine, Jiangsu University;Department of clinical laboratory of Wuxi No.2 people’s Hospital;  
Objective:To evaluate the clinical value of circulating tumor cells(CTC) count in peripheral venous blood of patients with non-small cell lung carcinoma(NSCLC).Methods:Totally 50 patients with NSCLC in Wuxi No.2 peoples Hospital were selected for study from January 2013 to December 2013,35 patients with lung benign tumor and 28 normal volunteers were selected as the control groups.CTC collected from 3 mL venous blood of all people above were counted.Patients with 8.7 units or more CTC were judged to be positive.The relationship between the positive rate of CTC and the age,sex,pathological type and clinical stage was analyzed.Results:CTC count was significantly higher in NSCLC patients than in benign lung patients and healthy controls.CTC count in NSCLC patients was rarely related to the sex,age or the pathological type(P0.05) and was closely related to clinical stage(P0.0l).Among NSCLC patients,CTC count significantly increased along with tumor progression.Conclusion:The progression of patients with non-small-cell lung carcinoma was associated with the level of CTC count which can reflect the status of the patients to some extent.
【Fund】: 无锡市医院管理中心医学科技项目(YGZXQ1310)~~
【CateGory Index】: R734.2
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