Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

Measuring agreement in comparison of CA125 determined by three different immunoassay systems

ZHANG Qiaodi;XIE Erfu;ZHANG Yan;LING Yun;JIANG Li;XU Huaguo;Department of Laboratory Medicine,First Affiliated Hospital of Nanjing Medical University;  
Objective:To assess the agreement of three different chemiluminescent detection system of CA125 measurement by using Bland-Altman analysis.Methods:One hundreds serum samples were obtained from 100 patients.CA125 of these samples were measured by three different chemiluminescent detection system,including Roche,Beckman and Siemens.Bland-Altman analysis and Spearman correlation analysis were performed to assess the results of every two systems,and draw the limits of agreement as an evaluation of agreement of different systems.Results:The distribution of CA125 results of Roche,Beckman and Siemens system were 5.6~279.8,4.5~542.4and 4.5~350.0 U/mL,respectively.Spearman correlation analysis showed that the results of every two methods had good correlation,the correlation coefficient were 0.932(P=0.000) between Roche and Beckman,0.947(P=0.000) between Roche and Siemens,0.948(P=0.000) between Beckman and Siemens.Bland-Altman analysis for the measurements showed bad relativity.The Bland-Altman plot revealed lower agreement between every two methods for CA125 results.Conclusion:Three detection systems do not have the consistency of the CA125 results,it is recommended to establish a standardized reference system of CA125 for comparison.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved