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Clinical pathological analysis of 1769 cases of placenta

CHEN Fangfang;LI Weidong;ZHANG Yanli;Department of Pathology,Shenzhen Bao'an District Maternity & Child Healthcare Hospital;  
Objective:Acute chorioamnionitis can cause severe complications for the infant,the aim of this study was to compare the incidence of adverse pregnancy outcome in groups of women with and without this condition during pregnancy.Methods:In this single centre study,1 769 placental tissue samples,collected between July2013~July 2014,from women classified as having high risk pregnancy were divided into study(n=872) and control(n=897) groups based on pathological diagnosis of acute chorioamnionitis.Adverse pregnancy outcomes,including inevitable abortion(IA),preterm premature rupture of membranes(PPROM),premature birth(PB),foetal distress(FD),neonatal asphyxia(NA) and gestational diabetes mellitus(GDM) were examined.Results:The incidence of IA,PPROM and PB was 185(21.21%),534(61.24%) and 232(26.62%) in the study group(n=872/l 769,49.30%),and 18(2.01%),467(52.26%) and 65(7.25%) in the control group(n=897/l 769,50.70%),respectively.There was a significant increase of these adverse pregnancy outcomes in the study group(P=0.000).The incidence of FD,NA and GDM was 96(11.00%),45(5.16%) and 48(5.50%) in the study group and 64(7.13%),35(3.90%),32(3.57%) in the control group,respectively.These were not statistically significant different between the 2 groups(P0.05).An interesting observation was that in the study group only175(20.07%) cases were covered by health insurance,whereas a significantly higher number(237,26.42%)of cases in the control group were insured(P=0.0016).Conclusion:In this single centre study we concluded that amongst women with high risk pregnancies,acute chorioamnionitis may cause high incidence of perinatal conditions and adverse pregnancy outcomes.The observation of disparity in health insurance between the 2groups also implies that the healthcare conditions as well as social and financial situations of the women may have also contributed to the incidence of acute chorioamnionitis and its adverse effects.
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