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《Journal of Clinical and Pathological Research》 2015-01
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Effect of carvedilol on vascular remodeling in carotid artery-injured rats

YUAN Xiangzhen;LIU Min;CAO Zhongchao;BAO Qiuhong;Health care center,Affiliated Hospital,Inner Mongolia Medical university;  
Objective:To explore the effect of carvedilol(CAR) on vascular remodeling in carotid artery-injured rats.Methods:Ninety Wistar rats were randomly divided into sham-operated group,injury group and CAR group,and the model of carotid balloon injury were established in the latter two groups.The rats were killed on the lst、3rd、7th、14th、28th day after injury.The intimal proliferation was observed by optical microscope.The expression of MMP-2,MMP-9 and TIMP-1 at different time points was detected by the method of immunohistochemistry and RT-PCR.Results:The intimal area(IA) and ratio of intimal and medial area(IA/MA) in CAR group were significantly lower than those in injury group,while lumen area was higher than its in injury group(P0.05).Compared to injury group,the expression of MMP-2 and MMP-9 significantly decreased in CAR group on the 3rd to 14 th day after injury(P0.05),while the expression of TIMP-1 had no difference between two groups.Conclusion:CAR could inhibit vascular remodeling and reduce restenosis,the mechanism of which may inhibit the expression of MMP-2 and MMP-9in carotid artery-injured rats,improve balance of synthesis and degradation of extracellular matrix.
【Fund】: 内蒙古自治区自然科学基金项目(2014MS08113)~~
【CateGory Index】: R543.4
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