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《Journal of Clinical and Pathological Research》 2015-01
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Research progress of HIMF and related signal pathways in pulmonary diseases

FANG Yanyan;DAI Aiguo;JIANG Yongliang;Provincial Mawandui Hospital Affiliated to University of South;Hunan Province Gerontology Research Institute;  
Hypoxia-induced mitogenic factor is a newly discovered emerging secreted protein,involved in developing processes of various pulmonary diseases.HIMF has proliferative,angiogenic,vasoconstrictive,and chemokinelike properties that upregulated intracellular calcium concentration,the production of inflammatory factor and growth factor to mediate the activity of cells.Currently,the previous study demonstrated that HIMF induced inflammatory,airway remodeling,vasoconstriction and vascular thickening through PLC-IP3,PI3K-Akt,BTK,Notch and other signal pathways.These could contribute to several diseases.Researches have explored the working mechanism of HIMF and provided new clue and target for disease treatment and prevention.This paper reviews and summarizes recent researches investigating HIMF and its related signal pathways in the development of pulmonary diseases.
【Fund】: 国家自然科学基金资助项目(81270118);; 湖南省研究生科研创新项目(CX2014B405)~~
【CateGory Index】: R563
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