Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

Research progress of sphingosine-1-phosphate and lung disease

DAI Fangfang;ZHU Liming;DAI Aiguo;Provincial Mawangdui Hospital Affiliated to University of South China;Hunan Province Gerontology Research Institute;  
Sphingosine-1-phosphate is one of the important components of a biologically active membrane and sphingolipid metabolites.It is important signaling molecules which regulates many biological functions in intracellular and extracellular.S1P combining with five kinds of G protein-coupled receptor subtypes(S1PR1-S1PR5) have different biological functions,including the regulation of cell proliferation,survival,apoptosis,inflammation and angiogenesis.Recent studies show that S1P and S1PR/SPHK play the important role in the development of lung disease,especially in bronchial asthma,pulmonary fibrosis,pneumonia,bronchiectasis,chronic obstructive pulmonary disease(COPD) and lung cancer.These studies may provide a new approach for the treatment of lung diseases.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved