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Ubiquitin C-terminal hydrolase 37

CAI Feng;SHI Yi;Department of Respiratory Medicine,Jinling Hospital,Medical school of Nanjing University;  
Ubiquitin C-terminal hydrolase 37(UCH37,also called UCHL5) is a member of the deubiquitinating enzymes,which is crucial to the ubiquitin-proteasome system(UPS).UCH37 is closely related with 19 S regulatory particles.In vitro,UCH37 could up-regulate transforming growth factor-β(TGF-β) signaling and inhibit cell apoptosis.UCH37 has been reported to be abnormally expressed in many human tumors and may be involved in the pathogenesis of Alzheimer's disease and diabetic nephropathy.Besides,the researches about the inhibitor of UCH37 and USP14 suggested a novel anticancer drug target.
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