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《Journal of Clinical and Pathological Research》 2015-01
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Research progress in chimeric antigen receptor modified T cells targeted glycoprotein tumor marker

MO Ran;WANG Dongjin;Department of Cardiothoracic Surgery,Nanjing Drum Tower Hospital,Nanjing University Medical School;  
Chimeric antigen receptor(CAR) modified T cells is an emerging targeted therapy CAR is consisted of single chain fragment variable(scFv),costimulatory molecules and T cells signal transduction domain,which could make T cells non-MHC-restricted targeting kill tumor cells.Experiments of CAR modified T cells in both animal models and clinical practice have got satisfied results.Glycoprotein tumor markers are promising targets of CAR modified T cells because of their favorable targeting.Targeted therapy researches aim at glycoprotein tumor marker revealed bright prospects in clinical applications.Nevertheless,some questions like off-target effect and disputed transfection ways should be considered as potential restricted factors in clinical application.We believe CAR modified T cells therapy targeted glycoprotein tumor marker could get more breakthroughs with in-depth researches.
【CateGory Index】: R730.51
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