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《Journal of Clinical and Pathological Research》 2015-01
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Research progress in chimeric antigen receptor modified T cells targeted glycoprotein tumor marker

MO Ran;WANG Dongjin;Department of Cardiothoracic Surgery,Nanjing Drum Tower Hospital,Nanjing University Medical School;  
Chimeric antigen receptor(CAR) modified T cells is an emerging targeted therapy CAR is consisted of single chain fragment variable(scFv),costimulatory molecules and T cells signal transduction domain,which could make T cells non-MHC-restricted targeting kill tumor cells.Experiments of CAR modified T cells in both animal models and clinical practice have got satisfied results.Glycoprotein tumor markers are promising targets of CAR modified T cells because of their favorable targeting.Targeted therapy researches aim at glycoprotein tumor marker revealed bright prospects in clinical applications.Nevertheless,some questions like off-target effect and disputed transfection ways should be considered as potential restricted factors in clinical application.We believe CAR modified T cells therapy targeted glycoprotein tumor marker could get more breakthroughs with in-depth researches.
【CateGory Index】: R730.51
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【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 WANG Feng;CAI Jing;JI Bin;Department of Oncology,Nantong Tumor Hospital;Department of Radiotherapy,Affiliated Hospital of Nantong University;;Efficiency of Three Dimensional Conformal Radiotherapy Combined with Concurrent GF Regimen Chemotherapy for Local Advanced Pancreatic Cancer[J];Journal of Chengdu Medical College;2013-06
2 GU Baoxiang;WANG Xiying;QIAO Mingxiao;XU Chunxiang;ZHANG Jiwei;CAO Zhilin;Resources and Environment Institute,Henan Institute of Engineering;Library of Henan Institute of Engineering;Zhengzhou Technical College;State Key Laboratory of Bioelectronics,Southeast University;;The Study of Phenol Pollution Water Detection Based on Nanostructure ZnO[J];Chinese Journal of Sensors and Actuators;2014-04
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4 Fabian Benencia;Biomedical Engineering Program, Russ College of Engineering and Technology,Ohio University;Molecular and Cell Biology Program, Ohio University;Department of Biomedical Sciences, Heritage College of Osteopathic Medicine Academic Research Center,Ohio University;;RNA vaccines for anti-tumor therapy[J];世界实验医学杂志(英文版);2013-04
5 ZHAO Kai;YIN Ling-Ling;ZHAO Dong-Mei;WU Qing-Yun;CHEN Chong;PAN Bin;ZENG Ling-Yu;YAO Yao;XU Kai-Lin;Laboratory of Transplantation Immunology,Xuzhou Medical College;Department of Hematology,The Affiliated Hospital of Xuzhou Medical College;;Construction of Hybridoma Cells with IL1RAP as a New Marker for Leukemia Stem Cells and Detection of Its Monoclonal Antibody[J];Journal of Experimental Hematology;2013-06
6 Chen Jie;Wang Yuhuan;Luo Chenglin;Wang Huiqin;Luo Xiaoling;Shenzhen Hornetcorn Biotechnology Co.,Ltd;;Introduction of Chimeric Antigen Receptor-engineered T Cells and the Clinical Use for Anticancer[J];Chinese Journal of Cell Biology;2014-02
7 Feng Libo;Xia Dong;Department of Gastrointestinal Surgery,Affiliated Hospital of Luzhou Medical College;;Progress of immunotherapy on gastrointestinal malignancies[J];Chinese Journal of Clinicians(Electronic Edition);2014-03
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