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Research progress of Treg/Th17 and chronic obstructive pulmonary disease

TIAN Jing;DAI Aiguo;JIANG Yongliang;Provincial Mawangdui Hospital Affiliated to University of South China;Hunan Province Gerontology Research Institute;  
Chronic obstructive pulmonary disease(COPD) is a kind of disease about airway inflammation.It is a disease state characterized by airflow limitation that is not fully reversible and is progressive slowly.Recent research indicates that autoimmune reaction involved in the pathogenesis of this disease.CD4+ T-lymphocytes includes regulatory T-cells(Treg) and T helper 17 cells(Thl7),which are both important immune regulatory cells and then involved in a series of pathogenesis of inflammatory and autoimmune related disease,furthermore play an important role in the pathogenesis of airway inflammation and chronic obstructive pulmonary disease.They are mutually antagonistic in function and differentiation,once the balance relationship is destroyed,it will have very important significance in immune or inflammatory disease.
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