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Advances in intercellular adhesion molecule-1 and bronchial asthma

DENG Yanfeng;ZHU Liming;Provincial Mawangdui Hospital Affiliated to University of South China;Hunan Province Gerontology Research Institute;  
Intercellular adhesion molecule-1(ICAM-1,CD54) is a member of the immunoglobulin(Ig) superfamily.It is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into inflammatory tissue.Migration of leukocytes from the systemic circulation into inflamed lung tissue is mediated by interactions between leukocyte surface and endothelial adhesion molecules(e.g.,ICAM-l),which plays an important role in the pathogenesis of asthma.In this review we will elaborate the progress of ICAM-1 and its expression regulation in asthma research.
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