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《Journal of Clinical and Pathological Research》 2015-01
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Research advance of small gastrointestinal stromal tumors

WU Jingjing;ZHANG Sheng;Department of Pathology,First Affiliated Hospital of Fujian Medical University;  
Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract that account for 80%of all GISTs.According to the tumor size,mitotic index and location,GISTs can be divide into very low,low,intermediate,high risk category,respectively.Small GISTs defined as less than 2.0 cm in diameter.The clinical manifestations,biology behavior,genetics and prognosis of the different risk GISTs are obviously different.Clinical study found that the clinical manifestation and prognosis of small GISTs are significantly better than GISTs.C-Kit mutations are the drive gene in the development of GISTs,the mutations are similar in small GISTs and overt GISTs,and so the role of the mutations is controversial.In this paper,current studies about small GISTs in epidemiology,clinical manifestation,molecular genetics,treatment and prognosis are reviewed.
【CateGory Index】: R735
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