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《Journal of Clinical and Pathological Research》 2015-03
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Clinicopathological features of meningeal hemangiopericytoma

ZHANG Liangyun;LIU Fang;GUO Li;XU Xin;LUO Xiaoping;Department of Pathology, the First People's Hospital of FoShan;  
Objective: To investigate the clinicopathological features and dif ferential diagnosis of meningeal hemangiopericytoma(HPC). Methods: The clinic data and histopathology of nine patients with meningeal HPC were retrospectively analyzed, with follow-up from 15 to 95 months, and review of the literature.Results: The clinical characters commonly manifested as headache, dizzy, oncothlipsis and intracranial hypertension; CT or MRI scanning showed that the tumors connect to the meningeal and obvious enhancement by enhancement scanning. Histologically, the tumors were highly cellularity which shaped with round or oval nuclei, indistinct nucleoli. And numerous vascular patterns with "a staghorn configuration", the single tumor cell were surrounded by reticular fiber. Immunochemistry stains showed tumor cells focal positive for CD34 and negative for PR, only one case showed focal weakly positive for EMA. Seven cases of HPC were followed up from 15 to95 months, four cases reappeared and one of the four cases lumbar metastasis found in 38 months at er operating.Conclusion: Meningeal HPC is an uncommon tumor and the finial diagnosis depends on pathological studying. Meningeal HPC is similar to the meningioma on CT or MRI scanning, but its biological behaviors, pathology features and prognosis dif ers from that of meningioma, with a high tendency for both local recurrence and distant metastasis, so that long time follow-up is necessary.
【CateGory Index】: R739.45
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