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《Journal of Clinical and Pathological Research》 2015-03
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Relationship between serum CA19-9, CEA levels and prognosis for patients with pancreatic cancer

WU Lei;HUANG Peijun;WANG Fang;LI Daqian;XIE Erfu;ZHANG Yan;PAN Shiyang;Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University;  
Objective: To explore the use of preoperative CA19-9 and CEA serum levels as prognostic factors to affect survival in pancreatic cancer. Methods: A retrospective review of the clinical records of 128 patients with pancreatic adenocarcinoma between January, 2012 and December, 2013 was performed. Kaplan-Meier method, log-rank test and Cox regression analysis models were used to investigate the relationship between the levels of CA19-9 and CEA and survival outcome. The cut-of for CA19-9, CEA was 39 U/m L and 4.7 ng/m L.Results: The mean age of 128 patients was 62 years, and the median survival time was 12.2 months. The positive rate of CA19-9 and CEA were respectively 78.1%, 37.5%. Patients with high CA19-9 or CEA levels suffered a poorer prognosis than the individuals with normal levels(CA19-9, P=0.027; CEA, P=0.036). Cox logistic analysis revealed that lymphatic metastasis, CA19-9 39 U/m L and CEA 4.7 ng/m L were independent prognostic factors.Conclusion: h e serum levels of preoperative CA19-9 and CEA were signii cant associated with survival time of pancreatic cancer patients, and could evaluate the prognosis of these patients.
【Fund】: 国家自然科学基金(81371894 81302531 81272324 81201359 81101322);; 江苏省实验诊断学重点实验室(XK201114);; 江苏高校优势学科建设工程基金项目~~
【CateGory Index】: R735.9;R730.43
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